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Collaborative care for comorbid depression and coronary heart disease: a systematic review and meta-analysis of randomised controlled trials

Identifieur interne : 003027 ( Main/Exploration ); précédent : 003026; suivant : 003028

Collaborative care for comorbid depression and coronary heart disease: a systematic review and meta-analysis of randomised controlled trials

Auteurs : Phillip J. Tully [Allemagne, Australie, France] ; Harald Baumeister [Allemagne]

Source :

RBID : PMC:4691772

Descripteurs français

English descriptors

Abstract

Objectives

To systematically review the efficacy of collaborative care (CC) for depression in adults with coronary heart disease (CHD) and depression.

Design

Systematic review and meta-analysis.

Data sources

Electronic databases (Cochrane Central Register of Controlled Trials MEDLINE, EMBASE, PsycINFO and CINAHL) were searched until April 2014.

Inclusion criteria

Population, depression comorbid with CHD; intervention, randomised controlled trial (RCT) of CC; comparison, either usual care, wait-list control group or no further treatment; and outcome, (primary) major adverse cardiac events (MACE), (secondary) standardised measure of depression, anxiety, quality of life (QOL) and cost-effectiveness.

Data extraction and analysis

RevMan V.5.3 was used to synthesise the data as risk ratios (RRs), ORs and standardised mean differences (SMD) with 95% CIs in random effect models.

Results

Six RCTs met the inclusion criteria and comprised 655 participants randomised to CC and 629 participants randomised to the control group (total 1284). Collaborative depression care led to a significant reduction in MACE in the short term (three trials, RR 0.54; 95% CI 0.31 to 0.95, p=0.03) that was not sustained in the longer term. Small reductions in depressive symptoms were evident in the short term (6 trials, pooled SMD −0.31; 95% CI −0.43 to −0.19, p<0.00001) and depression remission was more likely to be achieved with CC (5 trials, OR 1.77; 95% CI 1.28 to 2.44, p=0.0005). Likewise, a significant effect was observed for anxiety symptoms (SMD −0.36) and mental QOL (SMD 0.24). The timing of the intervention was a source of between-group heterogeneity for depression symptoms (between groups p=0.04, I2=76.5%).

Conclusions

Collaborative depression care did not lead to a sustained reduction in the primary MACE end point. Small effects were observed for depression, depression remission, anxiety and mental QOL.

Trials registration number

PROSPERO CRD42014013653.


Url:
DOI: 10.1136/bmjopen-2015-009128
PubMed: 26692557
PubMed Central: 4691772


Affiliations:


Links toward previous steps (curation, corpus...)


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<front>
<div type="abstract" xml:lang="en">
<sec>
<title>Objectives</title>
<p>To systematically review the efficacy of collaborative care (CC) for depression in adults with coronary heart disease (CHD) and depression.</p>
</sec>
<sec>
<title>Design</title>
<p>Systematic review and meta-analysis.</p>
</sec>
<sec>
<title>Data sources</title>
<p>Electronic databases (Cochrane Central Register of Controlled Trials MEDLINE, EMBASE, PsycINFO and CINAHL) were searched until April 2014.</p>
</sec>
<sec>
<title>Inclusion criteria</title>
<p>Population, depression comorbid with CHD; intervention, randomised controlled trial (RCT) of CC; comparison, either usual care, wait-list control group or no further treatment; and outcome, (primary) major adverse cardiac events (MACE), (secondary) standardised measure of depression, anxiety, quality of life (QOL) and cost-effectiveness.</p>
</sec>
<sec>
<title>Data extraction and analysis</title>
<p>RevMan V.5.3 was used to synthesise the data as risk ratios (RRs), ORs and standardised mean differences (SMD) with 95% CIs in random effect models.</p>
</sec>
<sec>
<title>Results</title>
<p>Six RCTs met the inclusion criteria and comprised 655 participants randomised to CC and 629 participants randomised to the control group (total 1284). Collaborative depression care led to a significant reduction in MACE in the short term (three trials, RR 0.54; 95% CI 0.31 to 0.95, p=0.03) that was not sustained in the longer term. Small reductions in depressive symptoms were evident in the short term (6 trials, pooled SMD −0.31; 95% CI −0.43 to −0.19, p<0.00001) and depression remission was more likely to be achieved with CC (5 trials, OR 1.77; 95% CI 1.28 to 2.44, p=0.0005). Likewise, a significant effect was observed for anxiety symptoms (SMD −0.36) and mental QOL (SMD 0.24). The timing of the intervention was a source of between-group heterogeneity for depression symptoms (between groups p=0.04, I
<sup>2</sup>
=76.5%).</p>
</sec>
<sec>
<title>Conclusions</title>
<p>Collaborative depression care did not lead to a sustained reduction in the primary MACE end point. Small effects were observed for depression, depression remission, anxiety and mental QOL.</p>
</sec>
<sec>
<title>Trials registration number</title>
<p>PROSPERO CRD42014013653.</p>
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